Patients 12 and over

2X weekly dosing can help align factor levels with the times you are physically active1

Talk to your doctor about which infusion days and dosage may be recommended for you. Your doctor will determine your dosage based on your age, weight, and bleeding pattern.

2 Infusion days per week

Many patients taking RIXUBIS® did not bleed over the course of the clinical study1

The efficacy and safety of RIXUBIS were evaluated in a prospective, open-label, uncontrolled, multicenter study of 73 male previously treated patients (PTPs) with severe or moderately severe hemophilia B who received RIXUBIS either for routine prophylaxis or on-demand treatment.6

  • In this study, many patients experienced 0 bleeds with RIXUBIS twice-weekly for a mean treatment duration of 6 months.6
43% of adults 12 and over experienced 0 bleeds 43% of adults 12 and over experienced 0 bleeds

Routine prophylactic treatment helped patients achieve a low Annualized Bleed Rate (ABR)*1

The median ABR in patients ≥12 years of age (n=56)1,6
Spontaneous Bleeds

Median ABR (range: 0.0-15.6)

Joint Bleeds

Median ABR (range: 0.0-21.5)

Total Bleeds

(range: 0.0-23.4)

*The majority of patients ≥12 years taking RIXUBIS had joint disease (88%) and target joints (66%) at screening.1

Know Your Annual Bleed Rate (ABR): Annual bleed rate is the number of bleeds a person experiences over the course of one year. If you don't have a year's worth of bleeds tracked, simply take the number of bleeds that you had in the last month and multiply by 12 as an estimate, which is your annualized bleed rate (ABR).

Most bleeds were resolved with 1 to 2 infusions1

85% of bleeds stopped with 1 to 2 infusions

With RIXUBIS, 96% of bleeding episodes were rated as having excellent or good bleed resolution.*1

*Excellent is defined as full relief of pain and cessation of objective signs of bleeding after a single infusion; no additional infusion is required for the control of bleeding; Good is defined as definite pain relief and/or improvement in signs of bleeding after a single infusion; possibly requires more than one infusion for complete resolution.

Selected Important Risk Information for RIXUBIS [Coagulation Factor IX (Recombinant)]

You should tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies, have any allergies, including allergies to hamsters, are nursing, are pregnant or planning to become pregnant, or have been told that you have inhibitors to factor IX.

Common side effects that have been reported with RIXUBIS include: unusual taste in the mouth, limb pain, and atypical blood test results.

The clinical trial demonstrated that recovery levels were consistent over time in all patient groups1

Patients 12 years and older recovery levels

Recovery levels

WHAT DOES RECOVERY MEAN?

Recovery is the name for the relative amount of factor IX in the bloodstream immediately after infusing. An average recovery is about 50%.3 Factor levels gradually decrease following infusion. Recovery is important to know because it helps your doctor determine the proper dose of factor your body needs and is measured by taking a blood test, also called an assay.3 Recovery is different for every person and may change for you over time. It can be influenced by age and weight and differs based on the factor product used.4,5

Talk to your doctor about what recovery levels mean for you.

+

Important Risk Information for RIXUBIS [Coagulation Factor IX (Recombinant)]

Please read below for Indications and Detailed Important Risk Information for RIXUBIS. See full Prescribing Information.

Indications for RIXUBIS [Coagulation Factor IX (Recombinant)]

RIXUBIS is an injectable medicine used to replace clotting factor IX that is missing in adults and children with hemophilia B (also called congenital factor IX deficiency or Christmas disease).

RIXUBIS is used to control and prevent bleeding in people with hemophilia B. Your healthcare provider may give you RIXUBIS when you have surgery. RIXUBIS can reduce the number of bleeding episodes when used regularly (prophylaxis).

Detailed Important Risk Information for RIXUBIS [Coagulation Factor IX (Recombinant)]

You should not use RIXUBIS if you are allergic to hamsters or any ingredients in RIXUBIS.

You should tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies, have any allergies, including allergies to hamsters, are nursing, are pregnant or planning to become pregnant, or have been told that you have inhibitors to factor IX.

Allergic reactions have been reported with RIXUBIS. Call your healthcare provider or get emergency treatment right away if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea, or fainting.

Your body may form inhibitors to factor IX. An inhibitor is part of the body's defense system. If you form inhibitors, it may stop RIXUBIS from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for development of inhibitors to factor IX.

If you have risk factors for developing blood clots, the use of factor IX products may increase the risk of abnormal blood clots.

Common side effects that have been reported with RIXUBIS include: unusual taste in the mouth, limb pain, and atypical blood test results.

Call your healthcare provider right away about any side effects that bother you or if your bleeding does not stop after taking RIXUBIS.

Please see RIXUBIS full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.