HCP Resources and Support

See if you're eligible to try RIXUBIS [Coagulation Factor IX (Recombinant)] for free.

FREEDOM OF CHOICE Free Trial Program

Your patients may be eligible to receive 4 free doses of RIXUBIS® along with valuable educational resources by enrolling in FREEDOM OF CHOICE.

Download and complete the enrollment form to get them started

Shire Hematology Support Center

From reimbursement and consent forms to billing codes and program descriptions, HSC has most RIXUBIS resources right at your fingertips.

Visit us
Or call us at 1-855-229-7377

Have questions?

A Local Shire Representitive is There to Help

A Local Shire Representitive is available to connect with you and help answer your questions about RIXUBIS.

Find a Local Shire Rep

CoPay assistance for RIXUBIS [Coagulation Factor IX (Recombinant)]. You may be eligible for up to $12,000 in support.

CoPay Assistance

Shire's CoPay Assistance Program offers financial assistance to eligible patients.

If your patients qualify, they may:
  • Save up to $12,000 every 12 months on RIXUBIS*
  • Receive reimbursement for their portion of their medication costs

CoPay Assistance

Shire's CoPay Assistance Program offers financial assistance to eligible patients.

If your patients qualify, they may:
  • Save up to $12,000 every 12 months on RIXUBIS*
  • Receive reimbursement for their portion of their medication costs
Your patients may be eligible for CoPay assistance if:
  • They are starting or receiving RIXUBIS for hemophilia B
  • They have commercial insurance that covers medication costs for RIXUBIS and allows for CoPay or coinsurance assistance

It's easy for patients to sign up for CoPay Assistance. They can call 1‑888‑229‑8379 Mon–Fri, 8:30 AM to 8:00 PM EST and answer a few simple questions about themselves and their pharmacy, or sign up on the HSC website at hematologysupport.com.

*Non-medication expenses, such as ancillary supplies or administration-related costs, are not eligible.

Must have a current prescription for RIXUBIS with an ICD-9 or ICD-10 code, as applicable, for hemophilia B.

Not valid for prescriptions reimbursed, in whole or in part, by Medicaid, Medicare, Medigap, VA, DoD, TRICARE or any other federal or state healthcare programs, including state pharmaceutical assistance programs, and where prohibited by the health insurance provider or by law.

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Patient counseling information

Please go over the information below with your patients before starting them on RIXUBIS. This does not include all the important information about RIXUBIS; see the RIXUBIS full Prescribing Information for the full details.

What is RIXUBIS?1

RIXUBIS is a medicine used to replace clotting factor (Factor IX) that is missing in people with hemophilia B. Hemophilia B is also called congenital factor IX deficiency or Christmas

RIXUBIS is a medicine used to replace clotting factor (Factor IX) that is missing in people with hemophilia B. Hemophilia B is also called congenital factor IX deficiency or Christmas disease. Hemophilia B is an inherited bleeding disorder that prevents blood from clotting normally.

RIXUBIS is used to prevent and control bleeding in people with hemophilia B. Your healthcare provider may give you RIXUBIS when you have surgery. RIXUBIS can reduce the number of bleeding episodes when used regularly (prophylaxis).

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Who should not use RIXUBIS?1

You should not use RIXUBIS if you:

You should not use RIXUBIS if you:

  • Are allergic to hamsters
  • Are allergic to any ingredients in RIXUBIS

Tell your healthcare provider if you are pregnant or breastfeeding because RIXUBIS may not be right for you.

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What should you tell your doctor before using RIXUBIS?1

You should tell your healthcare provider if you:

You should tell your healthcare provider if you:

  • Have or have had any medical problems
  • Take any medicines, including prescription and nonprescription medicines, such as over-the-counter medicines, supplements, or herbal remedies
  • Have any allergies, including allergies to hamsters
  • Are breastfeeding. It is not known if RIXUBIS passes into your milk and if it can harm your baby
  • Are pregnant or planning to become pregnant. It is not known if RIXUBIS may harm your unborn baby
  • Have been told that you have inhibitors to factor IX (because RIXUBIS may not work for you)
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How should you infuse RIXUBIS?1

RIXUBIS is given directly into the bloodstream.
RIXUBIS should be administered as ordered by your healthcare provider. You should

RIXUBIS is given directly into the bloodstream.

RIXUBIS should be administered as ordered by your healthcare provider. You should be trained on how to do infusions by your healthcare provider or hemophilia treatment center. Many people with hemophilia B learn to infuse RIXUBIS by themselves or with the help of a family member.

Your healthcare provider will tell you how much RIXUBIS to use based on your weight, the severity of your hemophilia B, and where you are bleeding.

You may have to have blood tests done after getting RIXUBIS to be sure that your blood level of factor IX is high enough to clot your blood.

Call your healthcare provider right away if your bleeding does not stop after taking RIXUBIS.

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What are the possible side effects of RIXUBIS?1

Allergic reactions may occur with RIXUBIS. Call your doctor or get emergency treatment right away if you get a rash or hives, itching, tightness of the throat, chest pain or tightness,

Allergic reactions may occur with RIXUBIS. Call your doctor or get emergency treatment right away if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea, or fainting. Some common side effects of RIXUBIS were unusual taste in the mouth and limb pain.

Tell your healthcare provider about any side effects that bother you or do not go away. These are not all the side effects possible with RIXUBIS. You can ask your healthcare provider for information that is written for healthcare professionals.

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What are the RIXUBIS dosage strengths?1

RIXUBIS comes in five different dosage strengths: 250 International Units (IU), 500 IU, 1000 IU, 2000 IU, and 3000 IU. The actual strength will be imprinted on the label and on

RIXUBIS comes in five different dosage strengths: 250 International Units (IU), 500 IU, 1000 IU, 2000 IU, and 3000 IU. The actual strength will be imprinted on the label and on the box. The five different strengths are color coded, as follows:

Always check the actual dosage strength printed on the label to make sure you are using the strength prescribed by your healthcare provider. Always check the expiration date printed on the box. Do not use the product after the expiration date printed on the box.

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How should you store RIXUBIS?1

Store at refrigerated temperature [2°C to 8°C (36°F to 46°F)] or room temperature [not to exceed 30°C (86°F)] for up to 36 months. Do not freeze.
  • Store at refrigerated temperature [2°C to 8°C (36°F to 46°F)] or room temperature [not to exceed 30°C (86°F)] for up to 36 months. Do not freeze.
  • Do not use after the expiration date printed on the carton or vial.
  • Reconstituted product (after mixing dry product with wet diluent) must be used within 3 hours and cannot be stored or refrigerated. Discard any RIXUBIS left in the vial at the end of your infusion.
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What else should you know about RIXUBIS?1

Your body may form inhibitors to factor IX. An inhibitor is part of the body’s defense system. If you form inhibitors, it may stop RIXUBIS from working properly. Consult with your

Your body may form inhibitors to factor IX. An inhibitor is part of the body’s defense system. If you form inhibitors, it may stop RIXUBIS from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to factor IX.

Medicines are sometimes prescribed for purposes other than those listed here. Do not use RIXUBIS for a condition for which it is not prescribed. Do not share RIXUBIS with other people, even if they have the same symptoms that you have.

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Important Risk Information for RIXUBIS [Coagulation Factor IX (Recombinant)]

Please read below for Indications and Detailed Important Risk Information for RIXUBIS. See full Prescribing Information.

Indications for RIXUBIS® [Coagulation Factor IX (Recombinant)]

RIXUBIS® [Coagulation Factor IX (Recombinant)] is an antihemophilic factor indicated in adults and children with hemophilia B for control and prevention of bleeding episodes, perioperative management, and routine prophylaxis.

RIXUBIS is not indicated for induction of immune tolerance in patients with hemophilia B.

Detailed Important Risk Information for RIXUBIS® [Coagulation Factor IX (Recombinant)]

CONTRAINDICATIONS

RIXUBIS is contraindicated in patients who have:

  • Known hypersensitivity to RIXUBIS or its excipients including hamster protein
  • Disseminated Intravascular Coagulation (DIC)
  • Signs of fibrinolysis

WARNINGS AND PRECAUTIONS

Hypersensitivity Reactions
Hypersensitivity reactions, including anaphylaxis, may occur. Should symptoms occur, discontinue RIXUBIS and administer appropriate treatment. Patients may also develop hypersensitivity to hamster (CHO) protein, which is present in trace amounts in the product.

Inhibitors
Development of neutralizing antibodies (inhibitors) to RIXUBIS may occur. Regularly evaluate patients for the development of factor IX inhibitors by appropriate clinical observations and laboratory tests. If expected factor IX plasma activity levels are not attained, or if bleeding is not controlled with an expected dose, perform an assay that measures factor IX inhibitor concentration. Patients with factor IX inhibitors are at an increased risk of severe hypersensitivity reactions or anaphylaxis if re-exposed to RIXUBIS.

Nephrotic Syndrome
Nephrotic syndrome has been reported following attempted immune tolerance induction with factor IX products in hemophilia B patients that have factor IX inhibitors. The safety and efficacy of using RIXUBIS for immune tolerance induction have not been established.

Thromboembolic Complications
The use of factor IX containing products has been associated with the development of thromboembolic complications. Monitor patients for early signs of thromboembolic and consumptive coagulopathy, when administering RIXUBIS to patients with liver disease, with signs of fibrinolysis, peri- and post-operatively, or at risk for thromboembolic events or DIC.

ADVERSE REACTIONS
Common adverse reactions observed in >1% of subjects in clinical studies were: dysgeusia, pain in extremity, and positive test for furin antibody.

Please see RIXUBIS full Prescribing Information.